With the main objective to produce a basis for advice to farmers concerning optimal ploughing depth under various conditions, a series of field experiments were initiated throughout Sweden. At 19 sites on various soils (clay content 72–521 g kg-1, organic matter content 21–89 g kg-1) mouldboard ploughing to about 15, 22 and 28 cm depth was repeated annually for up to 17 years. The total number of location-years was 241. Traditional farming had previously been practised at the sites, including annual mouldboard ploughing to 20–25 cm depth. Spring-sown barley (Hordeum vulgare L.) and oats (Avena sativa L.) were the most frequent crops but many other crops were grown less frequently. Crop residues were generally returned to the soil; straw was chopped at harvest. Post-emergence herbicides were regularly used, generally resulting in an adequate control of annual weeds. However, the control of perennial weeds, particularly couch grass (Elymus repens L. Gould) was often inadequate. At ploughing depths of 22 and 28 cm, the mean crop yields were 2% and 3%, respectively, higher than at 15 cm. However, the results varied considerably between sites. In soils with a high silt content, the shallowest ploughing resulted in up to 10% higher yield than deeper ploughing, provided the control of perennial weeds was adequate. The main reason seemed to be improved structural stability in the surface soil because the concentration of organic matter in this layer became higher the shallower the ploughing. In clay soils with relatively stable structure, as well as in sandy soils, the deepest ploughing resulted in the highest yields, probably because of the deeper loosening. At sites where perennial weeds imposed problems, the weed control was better the deeper the ploughing, sometimes increasing the relative yield after deeper ploughing by several percent as compared with shallow ploughing. Most of this effect was obtained already at the intermediate ploughing depth. The results led to the following conclusions for Swedish agriculture. It may be profitable to plough sandy soils annually as deep as 30 cm, coarse sandy soils perhaps even deeper. In clay and clay loam soils, ploughing deeper than 20–25 cm generally cannot be recommended. In silty soils with an unstable structure, mouldboard ploughing, if any, should be shallow (=15 cm), and perennial weeds should be controlled by other methods.